Strategies for the discovery of therapeutic aptamers
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چکیده
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“Nothing in biology makes sense except in the light of evolution” declared biologist Theodosius Dobzhansky in his seminal 1973 essay.1 This sentiment extends to aptamers, the topic highlighted in our special issue of Molecular Therapy—Nucleic Acids. Aptamers are short single-stranded oligonucleotides that can bind with high affinity and specificity to target molecules, and which are derived thr...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Discovery
سال: 2010
ISSN: 1746-0441,1746-045X
DOI: 10.1517/17460441.2011.537321